Which framework, created and maintained by ISACA, frames IT risk from a business leadership viewpoint and is used to manage and govern enterprise IT?

The correct choice, COBIT (Control Objectives for Information and Related Technologies), is a comprehensive framework developed by ISACA to help organizations manage and govern their IT resources effectively. It emphasizes the alignment of IT goals with business objectives, ensuring that IT supports and enhances overall business performance.

COBIT is particularly notable for framing IT risk from a business leadership perspective, which allows executives and board members to understand the importance of IT governance in the context of their broader organizational goals. This strategic viewpoint helps organizations identify and mitigate risks while also ensuring compliance with relevant regulations and standards.

In contrast, the other options, while important in their own right, do not address IT governance from a business leadership standpoint as effectively as COBIT. For instance, ISO 15408 is focused on common criteria for evaluating security technology, rather than governance. NIST 800-53 provides security and privacy controls, but it does not specifically center on business governance. NIST 800-61 guides incident handling processes but does not encompass the broader governance frameworks needed for overall IT management. Therefore, COBIT stands out as the best fit for managing and governing enterprise IT through a robust business leadership lens.